Title: Recent developments in the management of postmenopausal osteoporosis with bisphosphonates: enhanced efficacy by enhanced compliance
Authors: Boonen, Steven ×
Vanderschueren, Dirk
Venken, Katrien
Milisen, Koen
Delforge, Michel
Haentjens, Patrick #
Issue Date: Oct-2008
Publisher: Blackwell Scientific Publications
Series Title: Journal of Internal Medicine vol:264 issue:4 pages:315-332
Abstract: Bisphosphonates are the current mainstay of treatment for postmenopausal osteoporosis. Although daily oral dosing is effective, it is associated with poor compliance, partly because of the pre and postdose fasting and posture requirements. This negatively impacts treatment outcomes, leading to a reduced clinical benefit. Improved, yet still suboptimal adherence has been noticed with less frequent bisphosphonate dosing e.g. once-weekly and once-monthly oral regimens. The recently approved quarterly intravenous (i.v.) injection regimen of ibandronate and yearly i.v. infusion of zoledronic acid are attractive options in the management of postmenopausal osteoporosis. These regimens may assure quarterly and year long compliance.
ISSN: 0954-6820
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Hematology Section (-)
Academic Centre for Nursing and Midwifery
Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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