Title: Regulation of inositol 1,4,5-trisphosphate-induced Ca(2+) release by reversible phosphorylation and dephosphorylation
Authors: Vanderheyden, Veerle *
Devogelaere, Benoit *
Missiaen, Ludwig
De Smedt, Humbert
Bultynck, Geert
Parys, Jan # ×
Issue Date: Jun-2009
Publisher: Elsevier
Series Title: Biochimica et Biophysica Acta. Molecular Cell Research vol:1793 issue:6 pages:959-970
Abstract: The inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) is a universal intracellular Ca(2+)-release channel. It is activated after cell stimulation and plays a crucial role in the initiation and propagation of the complex spatio-temporal Ca(2+) signals that control cellular processes as different as fertilization, cell division, cell migration, differentiation, metabolism, muscle contraction, secretion, neuronal processing, and ultimately cell death. To achieve these various functions, often in a single cell, exquisite control of the Ca(2+) release is needed. This review aims to highlight how protein kinases and protein phosphatases can interact with the IP(3)R or with associated proteins and so provide a large potential for fine tuning the Ca(2+)-release activity and for creating efficient Ca(2+) signals in subcellular microdomains.
ISSN: 0167-4889
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
Physiology Section (-)
* (joint) first author
× corresponding author
# (joint) last author

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