Biochimica et Biophysica Acta. Molecular Cell Research vol:1793 issue:6 pages:959-970
The inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) is a universal intracellular Ca(2+)-release channel. It is activated after cell stimulation and plays a crucial role in the initiation and propagation of the complex spatio-temporal Ca(2+) signals that control cellular processes as different as fertilization, cell division, cell migration, differentiation, metabolism, muscle contraction, secretion, neuronal processing, and ultimately cell death. To achieve these various functions, often in a single cell, exquisite control of the Ca(2+) release is needed. This review aims to highlight how protein kinases and protein phosphatases can interact with the IP(3)R or with associated proteins and so provide a large potential for fine tuning the Ca(2+)-release activity and for creating efficient Ca(2+) signals in subcellular microdomains.