Title: Total synthesis of the antiviral peptide antibiotic feglymycin
Authors: Dettner, Frank ×
Hänchen, Anne
Schols, Dominique
Toti, Luigi
Nusser, Antje
Süssmuth, Roderich D #
Issue Date: 2009
Publisher: Wiley-VCH
Series Title: Angewandte Chemie - International Edition vol:48 issue:10 pages:1856-1861
Abstract: An adaptable approach: The first highly convergent stereoselective synthesis of feglymycin (see structure) and its enantiomer is based on the coupling of repeating peptide fragments. The use of weakly basic conditions throughout the synthesis suppressed the epimerization of sensitive aryl glycine units. Feglymycin has strong anti-HIV activity as well as potent (previously identified as weak) antibacterial activity against Staphylococcus aureus.
ISSN: 1433-7851
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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