Title: Inflammatory rather than infectious insults play a role in exocrine tissue damage in a mouse model for Coxsackievirus B4-induced pancreatitis
Authors: De Palma, Armando ×
Thibaut, Hendrik Jan
Li, Sandra
Van Aelst, Ilse
Dillen, Chris
Swinnen, Melissa
Verbeken, Erik
Neyts, Johan
Opdenakker, Ghislain #
Issue Date: Apr-2009
Publisher: Longman
Series Title: Journal of Pathology vol:217 issue:5 pages:633-641
Abstract: Infection with coxsackievirus B4 (CVB4) may result in an acute severe necrotizing pancreatitis that mostly remains restricted to the acini of the exocrine parenchyma. The mechanisms responsible for this tissue damage, however, remain poorly understood. We here report that COAM, a polyanionic carboxylic acid, provides marked protection against CVB4-induced pancreatitis in a mouse model. Despite the fact that COAM largely reduced disease severity, as detected by serum amylase and lipase levels as well as histologically, titres of replicating CVB4 in the pancreas were virtually unaffected. COAM treatment diminished the infection-associated MMP-9 levels and also resulted in a decreased influx of neutrophils into the infected pancreas. Moreover, we demonstrate that titres of replicating virus in the pancreas did not directly correlate with the severity of disease. In conclusion, our data suggest that immunopathological effects, rather than direct virus-induced destruction, are responsible for the damage to acinar tissue in CVB4-induced pancreatitis.
ISSN: 0022-3417
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Laboratory of Virology and Chemotherapy (Rega Institute)
Vesalius Research Centre (-)
× corresponding author
# (joint) last author

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