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Title: Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy
Authors: Allegaert, Karel ×
Van Mieghem, Tim
Verbesselt, René
de Hoon, Jan
Rayyan, Maissa
Devlieger, Roland
Deprest, Jan
Anderson, Brian J #
Issue Date: Feb-2009
Publisher: Mosby, Inc.
Series Title: American Journal of Obstetrics and Gynecology vol:200 issue:2 pages:170.e1-7
Abstract: OBJECTIVE: To study cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy. STUDY DESIGN: Newly collected time-concentrations profiles and reported studies investigating cefazolin disposition (plasma, amniotic fluid) were pooled. Nonlinear mixed effect modeling was applied. A 2-compartment linear disposition model was used to fit cefazolin plasma observations. A third compartment was used to model amniotic fluid concentration. RESULTS: One hundred eighty-seven plasma and 96 amniotic fluid samples were collected in 82 pregnancies (17-40 weeks gestational age). Cefazolin clearance and distribution estimates were 7.44 L/h and 12.04 L without gestational age-dependent trends in maternal plasma. The equilibration half-life (T(eq)) between plasma and amniotic fluid at term gestational age was 4.4 hours, increased with decreasing gestational age, and was 9.09 times longer in patients with polyhydramnios. CONCLUSION: Cefazolin clearance and distribution volume are increased during pregnancy. The cefazolin T(eq) depends on gestational age and polyhydramnios. On the basis of these observations, dosing regimes to attain higher amniotic fluid concentrations were formulated.
URI: 
ISSN: 0002-9378
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Newborn (-)
Section Woman - Miscellaneous (-)
Clinical Pharmacology Centre (-)
Pathophysiology of Pregnancy Section (-)
Basic Research in Gynaecology Section (-)
Foetal Medicine Section (-)
× corresponding author
# (joint) last author

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