Title: Synthesis of new cyclic and acyclic 5-halouridine derivatives as potential antiviral agents
Authors: Elshehry, Mohamed F ×
Balzarini, Jan
Meier, Chris #
Issue Date: Mar-2009
Publisher: Thieme Chemistry
Series Title: Synthesis issue:5 pages:841-847
Abstract: The synthesis of new cyclic and acyclic nucleoside analogues was achieved by alkylation of 5-halogenated 6-(2,4-dichlorophenoxymethyl)pyrimidine-2,4-dione following the Vorbruggen coupling procedure. Nucleoside analogues of the 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)-type were obtained as well as analogues of ganciclovir, acyclovir, and ribonucleosides. All compounds were tested against a variety of viruses. Three of the new compounds were potent and selective anti-HIV-1 inhibitors.
ISSN: 0039-7881
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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