Title: Prédiction anténatale de l'hypoplasie pulmonaire et traitement in-utero par occlusion trachéale foetale endoscopique (FETO) dans la hernie diaphragmatique congénitale isolée sévère
Other Titles: [Antenatal prediction of pulmonary hypoplasia and intrauterine treatment by endoscopic fetal tracheal occlusion in severe isolated congenital diaphragmatic hernia]
Authors: Gucciardo, Léonardo ×
Deprest, Jan
Vaast, Pascal
Favre, Romain
Gallot, Denis
Huissoud, Cyril
Bretelle, Florence
Agenor, Joel
Benachi, Alexandra
Jani, Jacques
Done, Elise
Van Mieghem, Tim
Ville, Yves
Devlieger, Roland #
Issue Date: Nov-2008
Publisher: Masson
Series Title: Bulletin de l'Académie Nationale de Médecine vol:192 issue:8 pages:1589-1607
Abstract: Congenital diaphragmatic hernia (CDH) affects one in 2500 to 5000 births and can be detected in utero by means of ultrasound screening Associated structural problems aggravate the prognosis. The survival rate is 70% or more for cases managed in tertiary care centers. The commonest causes of neonatal death in this setting are pulmonary hypoplasia and pulmonary hypertension. Prenatal imaging findings can now accurately predict postnatal outcome, based mainly on ultrasound determination of the lung-to-head ratio and liver position. This information can be used to counsel patients. In severe cases, prenatal intervention can reverse pulmonary hypoplasia. We review current data on prenatal prediction of neonatal survival. We also discuss experimental and clinical data on the benefits of fetal tracheal occlusion. The TOTAL trial (Tracheal Occlusion To Accelerate Lung growth) is currently ongoing in Europe.
ISSN: 0001-4079
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Foetal Medicine Section (-)
Section Woman - Miscellaneous (-)
× corresponding author
# (joint) last author

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