Title: Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability
Authors: Vinces, Marcelo *
Legendre, Matthieu *
Caldara, Marina
Hagihara, Masaki
Verstrepen, Kevin # ×
Issue Date: 29-May-2009
Publisher: Amer assoc advancement science
Series Title: Science vol:324 issue:5931 pages:1213-1216
Abstract: Relative to most regions of the genome, tandemly repeated DNA sequences display a greater propensity to mutate. A search for tandem repeats in the Saccharomyces cerevisiae genome revealed that the nucleosome-free region directly upstream of genes (the promoter region) is enriched in repeats. As many as 25% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters show significantly higher rates of transcriptional divergence. Variations in repeat length result in changes in expression and local nucleosome positioning. Tandem repeats are variable elements in promoters that may facilitate evolutionary tuning of gene expression by affecting local chromatin structure.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
* (joint) first author
× corresponding author
# (joint) last author

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