Title: Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension
Authors: Kuznetsova, Tatiana ×
Staessen, Jan A
Brand, Eva
Cwynar, Marcin
Stolarz, Katarzyna
Thijs, Lutgarde
Tikhonoff, Valérie
Wojciechowska, Wiktoria
Babeanu, Speranta
Brand-Herrmann, Stefan-Martin
Casiglia, Edoardo
Filipovský, Jan
Grodzicki, Tomasz
Nikitin, Yuri
Peleska, Jan
Struijker-Boudier, Harry
Bianchi, Giuseppe
Kawecka-Jaszcz, Kalina #
Issue Date: Feb-2006
Series Title: Journal of hypertension vol:24 issue:2 pages:235-42
Abstract: Hypertension is a chronic age-related disorder, affecting nearly 20% of all adult Europeans. This disease entails debilitating cardiovascular complications and is the leading cause for drug prescriptions in Europeans older than 50 years. Intensive research over the past two decades has so far failed to identify common genetic polymorphisms with a major impact on blood pressure or associated cardiovascular phenotypes, suggesting that multiple genes each with a minor impact, along with gene-gene and gene-environment interactions, play a role. The European Project on Genes in Hypertension (EPOGH) is a large-scale, family-based study in which participants from seven different populations were phenotyped and genotyped according to standardized procedures. This review article summarizes the initial 5-year findings and puts these observations into perspective against other published studies. The EPOGH demonstrated that phenotype-genotype relations strongly depend on host factors such as gender and lifestyle, in particular salt intake as reflected by the 24-h urinary excretion of sodium. The EPOGH therefore highlights the concept that phenotype-genotype relations can only be studied within a defined ecogenetic context.
ISSN: 0263-6352
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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