Title: Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis
Authors: Lories, Rik ×
Luyten, Frank
De Vlam, Kurt #
Issue Date: 2009
Publisher: BioMed Central Ltd.
Series Title: Arthritis Research & Therapy vol:11 issue:2 pages:221
Abstract: Targeted therapies that neutralize tumour necrosis factor are often able to control the signs and symptoms of spondyloarthritis. However, recent animal model data and clinical observations indicate that control of inflammation may not be sufficient to impede disease progression toward ankylosis in these patients. Bone morphogenetic proteins and WNTs (wingless-type like) are likely to play an important role in ankylosis and could be therapeutic targets. The relationship between inflammation and new bone formation is still unclear. This review summarizes progress made in our understanding of ankylosis and offers an alternative view of the relationship between inflammation and ankylosis.
ISSN: 1478-6354
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Rheumatology Section (-)
× corresponding author
# (joint) last author

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