Title: Is oral vitamin D a risk factor for prosthetic loosening ?
Authors: Peersman, Geert ×
Bellemans, Johan
Richart, Tom #
Issue Date: Feb-2009
Publisher: Acta medica belgica
Series Title: Acta Orthopaedica Belgica vol:75 issue:1 pages:2-7
Abstract: High counts of wear particles and activated macrophages are strong predictors of prosthetic loosening in total joint arthroplasty patients. The tissue response, dominated by macrophages, with production of inflammatory mediators and matrix-degrading enzymes, triggers a self-accelerating cycle of osteolysis, ultimately resulting in failure of the arthroplasty, high treatment cost and poor patient outcome. Vitamin D is frequently used as a treatment for osteoporosis, but might also contribute to osteolysis in inflammatory joints. Here, we review the effects of extrarenal vitamin D, activation by macrophages in the joint space. The summarized pathways contribute to increased bone resorption in the setting of the inflammatory micro-environment at the bone-prosthesis interface. If further evidence confirms a role of oral vitamin D, as a risk factor for aseptic loosening, this might influence the current treatment strategies for patients at risk for this condition.
ISSN: 0001-6462
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Orthopaedics Section (-)
Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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