Title: Triple-negative breast cancer
Authors: Stockmans, G.
Deraedt, K.
Wildiers, Hans
Moerman, Philippe
Paridaens, Robert # ×
Issue Date: Nov-2008
Publisher: Rapid Science Publishers
Series Title: Current Opinion in Oncology vol:20 issue:6 pages:614-620
Abstract: Purpose of review: Triple-negative breast cancer has been of great interest to oncologists because these cancers do not benefit from hormonal therapies or treatments targeted against human epidermal growth factor receptor 2 receptors. The only systemic therapy currently available is chemotherapy, and prognosis remains poor. We would like to describe recent pathological and genetic advancements and their possible implications on the development of new treatment strategies.
Recent findings: Increasing pathological and molecular knowledge has led to a better understanding of breast cancer in general. Triple-negative breast cancer, however, remains a heterogeneous subgroup with difficult-to-define subtypes. New targeted therapies are currently being developed and researched.
Summary: The recent advances in pathological and molecular knowledge have a pathological and clinical heterogeneous group. The main challenge lies in the development of new tailored treatment strategies for the various subgroups, with receptor kinase inhibition as the most promising new evolution to date. Further trials are needed to validate these new treatment options.
ISSN: 1040-8746
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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