ITEM METADATA RECORD
Title: Substrate based peptide aldehyde inhibits bacterial type I signal peptidase
Authors: Buzder-Lantos, Peter
Bockstael, Katrijn
Anné, Jozef
Herdewijn, Piet # ×
Issue Date: May-2009
Publisher: Pergamon-elsevier science ltd
Series Title: Bioorganic & medicinal chemistry letters vol:19 issue:10 pages:2880-2883
Abstract: Bacterial type I signal peptidase is a potential target for the development of novel antibacterial agents. In this study we demonstrate that a substrate based peptide aldehyde inhibits signal peptidases with a lower IC50 value than the lipopeptides described to date. The length of the core lipopeptide could be reduced by removing several amino acids from both termini. Conversion of this peptide to an aldehyde resulted in a molecule with an IC50 value of 0.09 mu M when tested against Saccharomyces aureus SPase I, SpsB. (C) 2009 Published by Elsevier Ltd.
URI: 
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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