Title: Synthesis of N-methyl-D-ribopyranuronamide nucleosides
Authors: Yang, Shiqiong
Busson, Roger
Herdewijn, Piet # ×
Issue Date: Oct-2008
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:64 issue:43 pages:10062-10067
Abstract: The Synthesis of N-methyl-D-ribopyranuronamide nucleosides is described. The key route is the rearrangement of a 1,2-O-isopropylidene protected furanose sugar with a carboxamide function in the 4-position to a ribopyranuronamide ring. The Lewis acid catalyzed condensation of adenine and thymine nucleobases with the per-O-acetylated N-methyl-D-ribopyranuronamide sugar is used to give the target nucleosides as a mixture of the alpha and beta anomers. The mixture was separated and the final Compounds were obtained by deacetylation in basic conditions. (C) 2008 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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