Title: Maturation of the Translation Inhibitor Microcin C
Authors: Metlitskaya, Anastasia
Kazakov, Teymur
Vondenhoff, Gaston
Novikova, Maria
Shashkov, Alexander
Zatsepin, Timofei
Semenova, Ekaterina
Zaitseva, Natalia
Ramensky, Vasily
Van Aerschot, Arthur ×
Severinov, Konstantin #
Issue Date: Apr-2009
Publisher: American Society for Microbiology (ASM)
Series Title: Journal of Bacteriology vol:191 issue:7 pages:2380-2387
Abstract: Microcin C (McC), an inhibitor of the growth of enteric bacteria, consists of a heptapeptide with a modified AMP residue attached to the backbone of the C-terminal aspartate through an N-acyl phosphamidate bond. Here we identify maturation intermediates produced by cells lacking individual mcc McC biosynthesis genes. We show that the products of the mccD and mccE genes are required for attachment of a 3-aminopropyl group to the phosphate of McC and that this group increases the potency of inhibition of the McC target, aspartyl-tRNA synthetase.
ISSN: 0021-9193
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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