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Title: Plasma levels of alpha-atrial natriuretic peptide in normal subjects under various postural conditions
Authors: Lijnen, Paul ×
M'Buyamba-Kabangu, J R
Huysecom, J
Fagard, Robert
Staessen, Jan A
Amery, A #
Issue Date: Dec-1987
Series Title: Methods and findings in experimental and clinical pharmacology vol:9 issue:12 pages:823-8
Abstract: The present paper describes a radioimmunoassay, in conjunction with an extraction procedure on octadecasilyl silica cartridges, of alpha-atrial natriuretic peptide in human plasma and its application in normal subjects under various postural conditions. The sensitivity of this assay is 1.96 pg/ml. The plasma concentrations of alpha-atrial natriuretic peptide in 18 normal male subjects ranged from 10 to 55 pg/ml. This assay was shown to be reproducible as indicated by the low within- and between-assay coefficients of variation. The plasma alpha-ANP concentration decreased during prolonged storage of the plasma at -20 degrees C or -80 degrees C and its level is also lower in hemolyzed plasma samples. The plasma alpha-ANP concentration is similar in standing and supine position but rose significantly when the subjects were tilted 20 degrees head-down.
ISSN: 0379-0355
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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