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Title: Porcine stentless bioprostheses: prevention of aortic wall calcification by dye-mediated photo-oxidation
Authors: Meuris, Bart ×
Phillips, R
Moore, Mark A
Flameng, Willem #
Issue Date: Jun-2003
Series Title: Artificial organs vol:27 issue:6 pages:537-43
Abstract: PURPOSE: Aortic wall calcification is problematic in stentless porcine valves. We evaluated the possible anticalcification effect of photo-oxidation on the aortic wall portion of porcine stentless bioprostheses. A comparison with glutaraldehyde-fixed tissue was made. METHODS: Six Photofix and six Freestyle valves were implanted in juvenile sheep in pulmonary position. Valves were explanted after 3 or 6 months and examined macroscopically, by x-ray, light, and transmission electron microscopy. Calcium content was determined by atomic absorption spectrometry. RESULTS: The aortic wall portion of all Photofix valves remained free from calcification, while the wall portion of glutaraldehyde-fixed valves calcified strongly, both after 3 and 6 months. Calcium content of the aortic wall portion was: 0.71 +/- 1.27 in the Photofix valves versus 10.78 +/- 77.22 in the Freestyle valves (P < 0.05). CONCLUSION: Photo-oxidation of a porcine stentless valve prevents calcification not only in the cusps but also in the aortic wall portion.
URI: 
ISSN: 0160-564X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Cardiac Surgery
Experimental Cardiac Surgery
× corresponding author
# (joint) last author

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