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Title: The synthesis of a novel C-nucleoside designed as guanosine analogue
Authors: Kourafalos, Vassilios N ×
Tite, Tony
Mikros, Emmanuel
Marakos, Panagiotis
Pouli, Nicole
Balzarini, Jan #
Issue Date: Dec-2008
Publisher: Georg thieme verlag kg
Series Title: Synlett issue:20 pages:3129-3132
Abstract: The syntheses of a novel C-nucleoside which can be viewed as 8-aza-3,9-dideazaguanosine, as well as or the corresponding heterocyclic base, are described. N-[4-(2,3,5-tri-O-Acetyl-beta-D-ribofuranosylmethyl)-2-methoxypyridin-3-yl]acetamide was regiospecifically nitrated and upon reduction and protection of the amino group underwent ring closure to the corresponding pyrazolopyridine derivative. The guanosine analogue was obtained via successive cleavage of the protecting groups.
ISSN: 0936-5214
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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