The synthesis of a novel C-nucleoside designed as guanosine analogue
Kourafalos, Vassilios N × Tite, Tony Mikros, Emmanuel Marakos, Panagiotis Pouli, Nicole Balzarini, Jan #
Georg thieme verlag kg
Synlett issue:20 pages:3129-3132
The syntheses of a novel C-nucleoside which can be viewed as 8-aza-3,9-dideazaguanosine, as well as or the corresponding heterocyclic base, are described. N-[4-(2,3,5-tri-O-Acetyl-beta-D-ribofuranosylmethyl)-2-methoxypyridin-3-yl]acetamide was regiospecifically nitrated and upon reduction and protection of the amino group underwent ring closure to the corresponding pyrazolopyridine derivative. The guanosine analogue was obtained via successive cleavage of the protecting groups.