Title: Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus
Authors: McGuigan, Christopher ×
Bidet, Olivier
Derudas, Marco
Andrei, Graciela
Snoeck, Robert
Balzarini, Jan #
Issue Date: Apr-2009
Publisher: Pergamon
Series Title: Bioorganic & Medicinal Chemistry vol:17 issue:8 pages:3025-3027
Abstract: Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta- alkenyl systems lose 3-4 orders of potency. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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