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Title: New antimony(III) bromide complexes with thioamides: synthesis, characterization, and cytostatic properties
Authors: Ozturk, Ibrahim I ×
Hadjikakou, Sotiris K
Hadjiliadis, Nick
Kourkoumelis, Nikolaos
Kubicki, Maciej
Tasiopoulos, Anastasios J
scleiman, Hanadi
Barsan, Mirela M
Butler, Ian S
Balzarini, Jan #
Issue Date: Mar-2009
Publisher: American Chemical Society
Series Title: Inorganic Chemistry vol:48 issue:5 pages:2233-2245
Abstract: New antimony(III) bromide complexes with the heterocyclic thioamides, thiourea (TU), 2-mercapto-1-methylimidazole (MMI), 2-mercapto-benzimidazole (MBZIM), 2-mercapto-5-methyl-benzimidazole (MMBZIM), 5-ethoxy-2-mercapto-benzimidazole (EtMBZIM), 2-mercapto-3,4,5,6-tetrahydro-pyrimidine (tHPMT), 2-mercaptopyridine (PYT), 2-mercapto-thiazolidine (MTZD), 3-methyl-2-mercaptobenzothiazole (MMBZT), and 2-mercaptopyrimidine (PMTH) of formulas [SbBr3(TU)(2)] (1), [SbBr3(MMI)(2)] (2), {[SbBr2(MBZIM)(4)](+) [Br](-) H2O} (3), {[SbBr2(mu(2)-Br)(MMBZIM)(2)](2)} (4), {[SbBr2(mu(2)-Br)(EtMBZIM)(2)](2) MeOH} (5), {[SbBr3(mu(2)- S-tHPMT)(tHPMT)](n)} (6), ([SbBr2(mu(2)-Br)(PYT)(2))(n)} (7), {[SbBr2(mu(2)-Br)(MTZD)(2)](n)} (8), [SbBr3(MMBZT)(2)] (9), and {[SbBr5](2-) [(PMTH2+)(2)]} (10) have been synthesized and characterized by elemental analysis, conductivity measurements, FTIR spectroscopy, FT-Raman spectroscopy, TG-DTA analysis, and X-ray powder diffraction. The crystal structures of 3, 4, 5, 6, 7, 8, and 10 were also determined by X-ray diffraction. In 3, four sulfur atoms from thione ligands and two bromide ions form an octahedral (O-h) cationic [SbS4Br2](+) species in which the two bromide anions lie at axial positions. A third bromide counteranion neutralizes the whole complex. 4 and 5 are dimers, whereas 6, 7 and 8 are polymers, built up by monomeric units of square pyramidal (SP) geometry around the metal center, which were formed by two sulfur atoms of thioamide ligands and three bromide ions. Finally, 10 is ionic salt containing 1D polymeric network of {[SbBr5](2-)}(n) anions and -[(PMTH2+)(2)] counter cations. in the lattice. The complexes showed mostly a moderate cytostatic activity against a variety of tumor cell lines.
ISSN: 0020-1669
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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