A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

Chamorro, Cristina; Kruijtzer, John AW; Farsaraki, Marina; Balzarini, Jan; Liskamp, Rob MJ

doi:10.1039/b817357e

A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

Author:

Chamorro, Cristina

Kruijtzer, John AW ; Farsaraki, Marina ; Balzarini, Jan ; Liskamp, Rob MJ

Keywords:

carboxyl protecting group, strategy, receptor, design, gp120, acids, Science & Technology, Physical Sciences, Chemistry, Multidisciplinary, Chemistry, CARBOXYL PROTECTING GROUP, STRATEGY, RECEPTOR, DESIGN, GP120, ACIDS, Amino Acid Sequence, Antibodies, Aza Compounds, Biomimetics, Epitopes, Heterocyclic Compounds, 2-Ring, Mass Spectrometry, Models, Molecular, Peptides, Cyclic, Protein Conformation, Proteins, 03 Chemical Sciences, Organic Chemistry, 34 Chemical sciences, 40 Engineering

Abstract:

In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.