Title: Tetrameric 1:1 and monomeric 1:3 complexes of silver(I) halides with tri(p-tolyl)-phosphine: A structural and biological study
Authors: Zartilas, Sotiris ×
Hadjikakou, Sotiris K
Hadjiliadis, Nick
Kourkoumelis, Nikolaos
Kyros, Loukas
Kubicki, Maciej
Baril, Martin
Butler, Ian S
Karkabounas, Spyros
Balzarini, Jan #
Issue Date: Feb-2009
Publisher: Elsevier
Series Title: Inorganica Chimica Acta Incorporating F-Block Elements vol:362 issue:3 pages:1003-1010
Abstract: Silver(I) halides react with tri(p-tolyl) phosphine (tptp, C21H21P) in MeOH/MeCN solutions in 1: 1 or 1: 3 molar ratios to give complexes of formulae {[AgCl(tptp)](4)} (1) or [AgX(tptp)(3)] (X = Cl (2), Br (3), I (4)), respectively. The complexes were characterized by elemental analyses, and FT-IR far-IR, FT-Raman, TG and H-1, C-13, P-31 NMR spectroscopic techniques. Crystal structures of complexes 2-4 were determined by X-ray diffraction at room temperature (rt). The crystal structure of 1 and 4 was also determined at 100(1) and 140(2) K (lt), respectively. In complex 1 four mu 3-Cl ions are bonded with four Ag(I) ions forming a cubane while the coordination sphere of silver(I) ions is completed by one P atom from a terminal tri(p-tolyl) phosphine ligand. In complexes 2-3 one terminal halogen and three P atoms from phosphine ligands form a tetrahedral arrangement around the metal ion. Complexes 1-4 were tested for in vitro cytostatic activity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a] pyrene) carcinogenesis and against murine leukemia (L1210) and human T-lymphocyte (Molt4/C8 and CEM) cells. The silver(I) complexes 1-4 show strong activity. (C) 2007 Elsevier B. V. All rights reserved.
ISSN: 0020-1693
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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