Title: Passive avoidance and spatial learning in ornithine transcarbamylase-deficient mice
Authors: D'Hooge, Rudi ×
Marescau, B.
Qureshi, I.A.
De Deyn, P.P. #
Issue Date: 2000
Host Document: Journal of Inherited Metabolic Disease vol:23 issue:suppl 1 pages:51-51
Conference: VIIIth International Congress of Inborn Errors of Metabolism edition:8 location:Cambridge - UK date:13-17 September 2000
Article number: 102-O
Abstract: Mutant sparse fur (spf) mice are a model for the congenital de¢ciency of ornithine transcarbamylase (OTC), the most common inborn error of urea synthesis in man. In this study, spf and control mice of 8-10 weeks old were behaviourally tested under normal (Arg +) or arginine-free (Arg -) diet conditions. Baseline plasma ammonia concentrations were signi¢cantly higher (202 þ 39 mM, n=7) than in controls (53.1 þ 9.6 mM, n=7). In spf mice, but to a lesser extend also in the control group, plasma ammonia concentration was signi¢cantly increased during Arg(-) diet. Performance of spf mice on Arg(+) diet in the passive avoidance learning test was normal, and they showed no evidence of impaired spatial learning and memory in the Morris water maze test. However, passive avoidance retention was impaired in spf mice which had been on Arg(-) diet during the training period. Mutant
mice on Arg(-) diet during the ¢rst 5 trial blocks of hidden-platform water maze acquisition also showed spatial acquisition and retention de¢cits. Learning to ¢nd a visible platform was not impaired in spf mice on Arg(-) diet. The learning and memory de¢cits described here might relate to the cognitive de¢cits seen in patients with OTC de¢ciency, and might be useful outcome measures in therapeutic studies using the spf model. (Supported by Born-Bunge Foundation and MRC Canada)
ISSN: 0141-8955
Publication status: published
KU Leuven publication type: IC
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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