Title: A mouse model for fragile-X mental retardation
Authors: D'Hooge, Rudi ×
Nagels, G.
Franck, F.
Willems, P.
Oostra, B.
De Deyn, P.P. #
Issue Date: 1995
Host Document: Abstract Booklet of the Annual Meeting: Belgische Vereniging voor Psychologie, Société Belge de Psychologie pages:4-4
Conference: Annual Meeting: Belgische Vereniging voor Psychologie, Société Belge de Psychologie location:Louvain-la-Neuve, Belgium date:12 May 1995
Abstract: Fragile-X syndrome is the most frequent form of inherited mental retardation in man. Male patients with fragile-X syndrome lack FMR1 protein due to silencing of the FMR1 gene. We designed a knockout model for fragile-X syndrome in mice. These animals, which lack Fmr1 protein, show a number of behavioural abnormalities. They display increased locomotor activity and exploratory behaviour as compared to their normal littermates. Passive avoidance learning was normal in Fmrl knockouts; visuo-spatial learning as measured by Morris water maze performance, on the other hand, was significantly impaired. We propose that the Fmrl knockout mouse might serve as the first mouse model of fragile-X mental retardation. Such a model is expected to facilitate greatly research on fragile-X mental retardation
Publication status: published
KU Leuven publication type: AMa
Appears in Collections:Laboratory for Biological Psychology
× corresponding author
# (joint) last author

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