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Title: Amplified-fragment length polymorphism analysis versus macro-restriction fragment analysis for molecular typing of Streptococcus pneumoniae isolates
Authors: Van Eldere, Johan
Janssen, P
Hoefnagels-Schuermans, A
van Lierde, S
Peetermans, Willy #
Issue Date: Jun-1999
Series Title: Journal of clinical microbiology vol:37 issue:6 pages:2053-7
Abstract: Forty-eight pneumococci were genotyped by on-line laser fluorescence amplified-fragment length polymorphism (AFLP) and pulsed-field gel electrophoresis (PFGE) analysis of chromosomal restriction fragments. Overall, the data generated by the two methods corresponded well. However, with AFLP, clusters were delineated at a higher similarity level, and isolate differentiation was more pronounced. AFLP and PFGE were equally efficient for assessing intraserotype diversity. We conclude that AFLP is a useful alternative to PFGE.
ISSN: 0095-1137
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Experimental and Clinical Microbiology (-)
Laboratory for Clinical Infectious and Inflammatory Disorders
Hospital Hygiene (-)
Laboratory of Clinical Bacteriology and Mycology
# (joint) last author

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