Title: Parathyroid hormone-stimulated calcium absorption in cTAL from vitamin D-deficient rabbits
Authors: Bourdeau, J E ×
Langman, C B
Bouillon, Roger #
Issue Date: Apr-1987
Publisher: Nature Pub. Group
Series Title: Kidney international vol:31 issue:4 pages:913-7
Abstract: Cortical thick ascending limbs of Henle's loop were dissected from the kidneys of chronically vitamin D-deficient or -replete rabbits and perfused in vitro. Unidirectional transepithelial calcium fluxes from lumen to bath were measured with 45Ca. The tubules were bathed in a solution containing 150 mM sodium and perfused with a solution containing 60 mM sodium to simulate conditions in the cortical thick ascending limb in vivo. Transepithelial voltages were equal across tubules from vitamin D-deficient and -replete rabbits. Likewise, baseline and parathyroid hormone-stimulated calcium fluxes were the same in tubules from the two groups. Because calcidiol and calcitriol were undetectable in the serum of the vitamin D-deficient rabbits, we suggest that neither of these endogenous vitamin D metabolites is essential in the regulation of calcium absorption in this portion of the rabbit nephron.
ISSN: 0085-2538
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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