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Title: Interleukin 6, a possible autocrine growth and differentiation factor for the human megakaryocytic cell line, CMK
Authors: Fuse, A ×
Kakuda, H
Shima, Y
Van Damme, Jozef
Billiau, Alfons
Sato, T #
Issue Date: Jan-1991
Series Title: British Journal of Haematology vol:77 issue:1 pages:32-6
Abstract: CMK is a human cell line derived from a megakaryoblastic leukaemia. It has characteristics of the megakaryocytic lineage, such as the presence of platelet peroxidase, membrane glycoproteins (GP)Ib and GPIIb/IIIa, alpha-granules, and demarcation membranes. The cell line proliferates autonomously in serum-containing medium. Here we report that the cell line expresses the gene for IL-6 and releases small quantities of the cytokine into the medium. Addition of exogenous IL-6 to cultures seeded into medium was found to promote growth of the cells. Conversely, addition of a neutralizing anti-IL-6 antibody inhibited cell growth. These data support the notion that autocrine IL-6 is one of the factors accounting for autonomous growth of the cell line.
ISSN: 0007-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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