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Title: Vitamin D-binding protein (Gc-globulin) binds actin
Authors: Van Baelen, Hugo ×
Bouillon, Roger
De Moor, Pieter #
Issue Date: Mar-1980
Publisher: American Society for Biochemistry and Molecular Biology
Series Title: Journal of Biological Chemistry vol:255 issue:6 pages:2270-2
Abstract: Actin, an ubiquitous highly conserved intracellular protein, and the serum vitamin D-binding protein (DBP) form tight 1:1 molar complexes in vitro. This interaction, which is not species-specific, explains the widespread occurrence of the 5-6 S protein responsible for the binding of 25-hydroxycholecalciferol in high speed supernatants of all nucleated tissues. Incubation of F-actin, the filamentous form of this protein, with DBP leads to depolymerization of the former. Actin, complexed with deoxyribonuclease I, retains its ability to bind DBP. Erythrocyte actin, prepared from red cell ghosts, also displays binding properties for DBP. The biological significance of this new interaction of actin is not yet understood.
ISSN: 0021-9258
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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