Title: Homogeneous interferon-beta-inducing 22K factor (IL-1 beta) has connective tissue cell stimulating activities
Authors: Bunning, R A ×
Van Damme, Jozef
Richardson, H J
Hughes, D E
Opdenakker, Ghislain
Billiau, Alfons
Russell, R G #
Issue Date: Sep-1986
Series Title: Biochemical and Biophysical Research Communications vol:139 issue:3 pages:1150-7
Abstract: The human interferon-beta-inducing 22K factor has been shown to have structural homologies with interleukin-1 beta (IL-1 beta) and some of the activities attributed to IL-1. We have shown that 22K factor, purified to homogeneity and endotoxin free, has connective tissue cell stimulating activities, indicating that these activities are due to a naturally occurring species of IL-1 beta and not contaminating factors. 22K factor stimulated the production of prostaglandin E, caseinase activity and plasminogen activator activity in human articular chondrocytes in culture. This cell system appears highly sensitive to 22K factor activity. 22K factor also stimulated the resorption of bovine nasal cartilage and neonatal mouse calvaria.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Academic Center for General Practice
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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