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Title: Timing of extinction relative to acquisition: A parametric analysis of fear extinction in humans
Authors: Norrholm, Seth D ×
Vervliet, Bram
Jovanovic, Tanja
Boshoven, William
Myers, Karyn M
Davis, Michael
Rothbaum, Barbara
Duncan, Erica J #
Issue Date: 2008
Publisher: Amer psychological assoc
Series Title: Behavioral Neuroscience vol:122 issue:5 pages:1016-1030
Abstract: Fear extinction is a reduction in conditioned fear following repeated exposure to the feared cue in the absence of any aversive event. Extinguished fear often reappears after extinction through spontaneous recovery. Animal studies suggest that spontaneous recovery can be abolished if extinction occurs within minutes of acquisition. However, a limited number of human extinction studies have shown that short interval extinction does not prevent the return of fear. For this reason. we performed an in-depth parametric analysis of human fear extinction using fear-potentiated startle. Using separate single-cue and differential conditioning paradigms, participants were fear conditioned and then underwent extinction either 10 min (Immediate) or 72 hr (Delayed) later. Testing for spontaneous recovery occurred 96 hr after acquisition. In the single cue paradigm, the Immediate and Delayed groups exhibited differences in context, but not fear, conditioning. With differential conditioning, there were no differences in context conditioning and the Immediate group displayed less spontaneous recovery. Thus, the results remain inconclusive regarding spontaneous recovery and the timing of extinction and are discussed in terms of performing translational studies of fear in humans.
URI: 
ISSN: 0735-7044
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Psychology of Learning and Experimental Psychopathology
× corresponding author
# (joint) last author

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