Title: Bdellovibrio bacteriovorus Attacks Aggregatibacter actinomycetemcomitans
Authors: Van Essche, Mark
Quirynen, Marc
Sliepen, Isabelle
Van Eldere, Johan
Teughels, Wim # ×
Issue Date: Feb-2009
Publisher: Sage publications inc
Series Title: Journal of Dental Research vol:88 issue:2 pages:182-186
Abstract: Periodontitis is a polymicrobial infectious disease primarily associated with Gram-negative periodontopathogens. Bdellovibrio and like organisms are predatory bacteria that feed on Gram-negative bacteria. This study investigated whether predatory bacteria can attack Aggregatibacter actinomycetemcomitans. Therefore, A. actinomycetemcomitans was challenged with the predator Bdellovibrio bacteriovorus under conditions simulating the oral cavity. The reduction of planktonic A. actinomycetemcomitans was quantified via bacterial culture, and the development of predatory bacteria was monitored with quantitative real-time PCR. The destruction of A. actinomycetemcomitans biofilms by B. bacteriovorus was quantified by crystal violet staining and visualized by scanning electron microscopy. The in vitro results show that B. bacteriovorus can attack, prey on, and kill A. actinomycetemcomitans and suggest a potential for B. bacteriovorus as a living antibiotic for the prevention and treatment of periodontitis.
ISSN: 0022-0345
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Periodontology
Faculty of Medicine - miscellaneous
Laboratory for Experimental and Clinical Microbiology (-)
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
40.docxpreprint Published 27KbUnknownView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science