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Title: Lack of effect of the vitamin D status on the concentration of the vitamin D-binding protein in rat serum
Authors: Bouillon, Roger ×
Vandoren, G
Van Baelen, Hugo
De Moor, Pieter #
Issue Date: Jul-1980
Series Title: Endocrinology vol:107 issue:1 pages:160-3
Abstract: The influence of the vitamin D status on the concentration of the serum vitamin D-binding protein was studied. In normal rats the serum vitamin D-binding protein increases gradually from birth to adulthood; after puberty a higher concentration is found in male rats than in female rats. Rats fed a vitamin D-deficient diet containing a sufficient amount of calcium and phosphorus were found to have a normal DBP (binding protein for vitamin D and its hydroxylated metabolites) pattern indistinguishable from that of rats receiving the same diet but supplemented with a weekly injection of 500 microgram vitamin D3. Rats fed a vitamin D-deficient, low calcium, low phosphorus diet developed severe hypocalcemia and growth retardation, but their DBP pattern was not significantly different from that of rats fed the same diet but supplemented with a weekly injection of 500 microgram vitamin D3. The concentration of the transport protein for vitamin D was thus unrelated to the vitamin D status of the rat.
ISSN: 0013-7227
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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