Title: Routine patch testing with frullanolide mix: an European Environmental and Contact Dermatitis Research Group multicentre study
Authors: Ducombs, G ×
Lepoittevin, J P
Berl, V
Andersen, K E
Brandão, F M
Bruynzeel, D P
Bruze, M
Camarasa, J G
Frosch, P J
Goossens, An
Lachapelle, J M
Lahti, A
Le Coz, C J
Maibach, H I
Menné, T
Seidenari, S
Shaw, S
Tosti, A
Wilkinson, J D #
Issue Date: Mar-2003
Series Title: Contact dermatitis vol:48 issue:3 pages:158-61
Abstract: Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.
ISSN: 0105-1873
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Dermatology
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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