Routine patch testing with frullanolide mix: an European Environmental and Contact Dermatitis Research Group multicentre study
Ducombs, G × Lepoittevin, J P Berl, V Andersen, K E Brandão, F M Bruynzeel, D P Bruze, M Camarasa, J G Frosch, P J Goossens, An Lachapelle, J M Lahti, A Le Coz, C J Maibach, H I Menné, T Seidenari, S Shaw, S Tosti, A Wilkinson, J D #
Contact dermatitis vol:48 issue:3 pages:158-61
Contact sensitivity to plants containing 1 or more sesquiterpene lactones (SLs) is difficult to diagnose. The mixture of SLs (SL mix) has been shown to detect only about 60% of sensitized individuals. In order to improve the diagnosis of sensitization to plants containing SLs, we have tested a mixture of frullanolides contained in Frullania dilatata and Frullania tamarisci at 3 different concentrations (0.01%, 0.033% and 0.1% in petrolatum). 8605 consecutive eczema patients in 1 North American and 15 European dermatology departments were tested with this mix, and 0.35% of positive cases to the different concentrations were found. Routine use of this mix permitted detection of only a small percentage of extra cases and did not improve the SL mix score. The frullanolide mix should therefore be restricted to investigations in particular geographical zones and/or in particular occupations.