Title: Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited
Authors: Loges, Sonja
Mazzone, Max
Hohensinner, Philipp
Carmeliet, Peter # ×
Issue Date: Mar-2009
Publisher: Cell Press
Series Title: Cancer Cell vol:15 issue:3 pages:167-170
Abstract: Clinical practice reveals that therapy with angiogenesis inhibitors often does not prolong survival of cancer patients for more than months, because tumors elicit evasive resistance. In this issue of Cancer Cell, two papers report that VEGF inhibitors reduce primary tumor growth but promote tumor invasiveness and metastasis. These perplexing findings help to explain resistance to these drugs but raise pertinent questions of how to best treat cancer patients with antiangiogenic medicine in the future. We discuss here how VEGF inhibitors can induce such divergent effects on primary tumor growth and metastasis.
ISSN: 1535-6108
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven Centre for Cancer Biology) (+)
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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