Title: Loss of the Cholesterol-Binding Protein Prominin-1/CD133 Causes Disk Dysmorphogenesis and Photoreceptor Degeneration
Authors: Zacchigna, Serena
Oh, Hideyasu
Wilsch-Braeuninger, Michaela
Missol-Kolka, Ewa
Jaszai, Jozsef
Jansen, Alexandra
Tanimoto, Naoyuki
Tonagel, Felix
Seeliger, Mathias
Huttner, Wieland B
Corbeil, Denis
Dewerchin, Mieke
Vinckier, Stefan
Moons, Lieve
Carmeliet, Peter # ×
Issue Date: Feb-2009
Publisher: Soc neuroscience
Series Title: Journal of Neuroscience vol:29 issue:7 pages:2297-2308
Abstract: Prominin-1/CD133 (Prom-1) is a commonly used marker of neuronal, vascular, hematopoietic and other stem cells, yet little is known about its biological role and importance in vivo. Here, we show that loss of Prom-1 results in progressive degeneration of mature photoreceptors with complete loss of vision. Despite the expression of Prom-1 on endothelial progenitors, photoreceptor degeneration was not attributable to retinal vessel defects, but caused by intrinsic photoreceptor defects in disk formation, outer segment morphogenesis, and associated with visual pigment sorting and phototransduction abnormalities. These findings shed novel insight on how Prom-1 regulates neural retinal development and phototransduction in vertebrates.
ISSN: 0270-6474
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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