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Title: Lack of interaction between famotidine and warfarin
Authors: De Lepeleire, I ×
Van Hecken, Anne
Verbesselt, René
Tjandra-Maga, Tikma Budya
Buntinx, A
Distlerath, L
De Schepper, P J #
Issue Date: Jan-1990
Series Title: International journal of clinical pharmacology research vol:10 issue:3 pages:167-71
Abstract: In eight healthy male volunteers taking daily subtherapeutic doses of warfarin (mean daily dose = 4.0 mg), the addition of famotidine 40 mg once-a-day for seven days did not alter the prothrombin time profile, thrombotest coagulation time or total warfarin steady-state plasma concentration. Plasma peak concentration, time to peak concentration and area under curve for famotidine were not affected by the co-administration of warfarin. However the plasma half-life of famotidine was slightly, but statistically significantly longer (p less than 0.05) during maintenance treatment with warfarin (mean +/- s.e.m.: 2.58 +/- 0.14 h versus 2.96 +/- 0.16 h respectively).
ISSN: 0251-1649
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Clinical Pharmacology Centre (-)
× corresponding author
# (joint) last author

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