Title: Role of group-specific component (vitamin D binding protein) in clearance of actin from the circulation in the rabbit
Authors: Goldschmidt-Clermont, P J ×
Van Baelen, Hugo
Bouillon, Roger
Shook, T E
Williams, M H
Nel, A E
Galbraith, R M #
Issue Date: May-1988
Publisher: American Society for Clinical Investigation
Series Title: Journal of Clinical Investigation vol:81 issue:5 pages:1519-27
Abstract: The possible role of group specific component (Gc) (vitamin D-binding protein) in the clearance of cellular actin entering the circulation was examined with 125I-labeled Gc and actin injected into a rabbit model. Although filamentous F-actin is depolymerized primarily by plasma gelsolin, greater than or equal to 90% 125I-actin injected in either monomeric G- or F-form became complexed eventually with Gc (1:1 molar ratio). Clearance of Gc complexes was much faster (greater than 90% within 5 h) than that of native Gc (t1/2 = 17.2 h). Nephrectomy did not significantly alter the clearance of either Gc or actin. Since Gc complexes are dramatically increased in situations of tissue necrosis such as in fulminant hepatic failure, the current results suggest a crucial role for Gc in sequestration and clearance of released cellular actin.
ISSN: 0021-9738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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