Title: Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo
Authors: Arredouani, Mohamed S ×
Kasran, Ahmad
Vanoirbeek, Jeroen
Berger, Frank G
Baumann, Heinz
Ceuppens, Jan #
Issue Date: Feb-2005
Series Title: Immunology vol:114 issue:2 pages:263-71
Abstract: We report that haptoglobin, an acute-phase protein produced by liver cells in response to interleukin-6 (IL-6), can modulate the inflammatory response induced by endotoxins. We provide evidence that haptoglobin has the ability to selectively antagonize lipopolysaccharide (LPS) effects in vitro by suppressing monocyte production of tumour necrosis factor-alpha, IL-10 and IL-12, while it fails to inhibit the production of IL-6, IL-8 and IL-1 receptor antagonist. In two animal models of LPS-induced bronchopulmonary hyperreactivity and endotoxic shock, haptoglobin knockout mice were more sensitive to LPS effects compared to their wild-type counterparts. The present data suggest that haptoglobin regulates monocyte activation following LPS stimulation. The increase in haptoglobin levels during an acute-phase reaction may generate a feedback effect which dampens the severity of cytokine release and protects against endotoxin-induced effects.
ISSN: 0019-2805
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Immunology
Occupational, Environmental and Insurance Medicine (-)
× corresponding author
# (joint) last author

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