Title: Toxicity of poly(rI).poly(rC) for interferon-treated cells. An ultrastructural evaluation
Authors: Heremans, Hubertine ×
Stewart, W E
Billiau, Alfons
De Somer, P #
Issue Date: Jan-1976
Series Title: Journal of General Virology vol:30 issue:1 pages:131-5
Abstract: The cytotoxic effect of poly(rI).poly(rC) for interferon-treated cells is preceded by discrete ultrastructural alterations in (1) the mitochondria: swelling of the cristae and increased density of their matrix, (2) the nucleus: disorganization of the structure, and (3) the endoplasmic reticulum: slight dilatation with disorganization and depletion of the filament bundles. Our results do not allow us to conclude whether any of these alterations is a primary effect of the treatment. Possibly they are secondary to some, as yet unknown, functional defect, and only reflect incipient cell death.
ISSN: 0022-1317
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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