Title: Administration of fibroblast interferon to patients with advanced breast cancer: possible effects on skin metastasis and on hormone receptors
Authors: Pouillart, P ×
Palangie, T
Jouve, M
Garcia-Giralt, E
Fridman, W H
Magdelenat, H
Falcoff, E
Billiau, Alfons #
Issue Date: Oct-1982
Series Title: European journal of cancer & clinical oncology vol:18 issue:10 pages:929-35
Abstract: Eleven patients with metastasized breast cancer received 8 intramuscular injections of 6 x 10(6) units of human fibroblast interferon over a period of 40 days. The injections did not cause local irritation or inflammation. Fever occurred in only 1 of the 11 patients. Although several types of metastases were monitored, only skin nodules consistently (10 out of 11 patients) exhibited changes that were suggestive of a therapeutic effect of the treatment regimen: either a simple decrease in size of some nodules or central necrosis accompanied by an inflammatory reaction. NK-activity of peripheral blood leukocytes was significantly increased after administration of the first dose; the effect of subsequent injections was less clear. Receptors for estrogens and progestogens were increased in the tumor biopsies of 2 out of 2 and 5 out of 6 patients tested respectively.
ISSN: 0277-5379
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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