Title: Selective synthesis of functionalized thia- and oxacalix[2]arene[2]pyrimidines
Authors: Maes, Wouter ×
Van Rossom, Wim
Van Hecke, Kristof
Van Meervelt, Luc
Dehaen, Wim #
Issue Date: Aug-2006
Publisher: American Chemical Society
Series Title: Organic Letters vol:8 issue:18 pages:4161-4164
Abstract: Functionalized oxacalix[m]arene[n]pyrimidines have been synthesized by S(N)Ar on 4,6-dihalopyrimidine building blocks. Depending on the S(N)Ar conditions, either a mixture of oxacalix[n]arenes, ranging from oxacalix[4]- up to oxacalix[12]arene, could be prepared or the oxacalix[4]arene could be synthesized selectively in a high yield. The electrophilic (pyrimidine) and the nucleophilic components could both be varied, allowing the preparation of functionalized oxacalix[4]arenes. Moreover, the procedure also gives access to the analogous thiacalix[4]arenes. [structure: see text]
ISSN: 1523-7060
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Biochemistry, Molecular and Structural Biology Section
Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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