Title: Interferon treatment of NZB mice: accelerated progression of autoimmune disease
Authors: Heremans, Hubertine ×
Billiau, Alfons
Colombatti, A
Hilgers, J
De Somer, P #
Issue Date: Sep-1978
Series Title: Infection and immunity vol:21 issue:3 pages:925-30
Abstract: The effect of long-term administration of interferon in New Zealand Black and New Zealand Black/New Zealand White F1 hybrid mice was studied. Treatment with moderate doses of interferon (10(4) units, five times weekly for 8 weeks) did not depress murine leukemia virus gp69/71 levels in serum and spleen, nor p30 levels in the spleen. Interferon given at 10(5.1) units (three times weekly for 37 weeks) caused an increased incidence of anti-erythrocyte antibodies in New Zealand Black mice. Finally, the hybrid mice given interferon at 10(6.0) units (three times weekly for 33 weeks) had increased renal immune complex deposits and increased incidences of proteinuria and anemia.
ISSN: 0019-9567
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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