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Title: Identification of an interleukin HP1-like plasmacytoma growth factor produced by L cells in response to viral infection
Authors: Cayphas, S ×
Van Damme, Jozef
Vink, A
Simpson, R J
Billiau, Alfons
Van Snick, J #
Issue Date: Nov-1987
Series Title: Journal of Immunology vol:139 issue:9 pages:2965-9
Abstract: We have recently purified and partially sequenced a new T cell-derived lymphokine with growth factor activity for B cell hybridomas and plasmacytomas, which we named interleukin HP1 (HP1). Here we show that, in response to viral infection or after treatment with poly(rI).poly(rC), L cells produce a factor that is capable of supporting the in vitro growth and survival of HP1-dependent cell lines. Serologic and structural evidence is presented in favor of the identity between the fibroblast factor and HP1, demonstrating that non-T cells can make HP1-related molecules.
ISSN: 0022-1767
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
Laboratory of Immunobiology (Rega Institute)
× corresponding author
# (joint) last author

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