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Title: Recombinant interferon-gamma induces HLA-DR expression on human corneal epithelial and endothelial cells in vitro: a preliminary report
Authors: el-Asrar, A M ×
van den Oord, Joost
Billiau, Alfons
Desmet, Valeer
Emarah, M h
Missotten, Luc #
Issue Date: Aug-1989
Series Title: British Journal of Ophthalmology vol:73 issue:8 pages:587-90
Abstract: The effect of interferon-gamma on the expression in situ of major histocompatibility complex (MHC) products in human corneas was studied in vitro. Incubation for four days with 5 or 50 mg/l of Escherichia coli-derived recombinant human interferon-gamma resulted in the appearance de novo of MHC class II or HLA-DR antigens on variable numbers of corneal epithelial cells as well as on corneal endothelium, whereas it had no effect on the expression of MHC class I or HLA-ABC antigens. These results may help to explain the mechanism underlying the expression of HLA-DR antigens on corneal and limbal epithelium in various inflammatory eye diseases.
ISSN: 0007-1161
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Translational Cell & Tissue Research
Alumni, Faculty of Medicine
× corresponding author
# (joint) last author

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