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Title: Tolerance and pharmacokinetics of propacetamol, a paracetamol formulation for intravenous use
Authors: Depré, Marleen ×
Van Hecken, Anne
Verbesselt, René
Tjandra-Maga, Tikma Budya
Gerin, M
de Schepper, P J #
Issue Date: Jan-1992
Series Title: Fundamental & clinical pharmacology vol:6 issue:6 pages:259-62
Abstract: In 12 healthy volunteers, paracetamol pharmacokinetics were compared following administration of 1 g propacetamol HCl given intravenously over a 15-min period and 500 mg paracetamol given orally. Mean +/- SD total AUC (microgram/ml.h) following the iv formulation was significantly (P < 0.01) greater than following oral paracetamol (25.53 +/- 4.27 vs 21.04 +/- 4.49) corresponding to a mean oral bioavailability of paracetamol of 82.2 +/- 9.4%. Between 1 and 2 h after administration, paracetamol plasma concentrations became very similar following both formulations. In another study, 2 g propacetamol HCl was given both as a 15-min infusion and as a 2-min bolus injection to six healthy volunteers. Contrary to mild to moderate local discomfort experienced during the 2-min bolus injection, the 15-min infusion was well tolerated without any complaints reported.
ISSN: 0767-3981
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Clinical Pharmacology Centre (-)
× corresponding author
# (joint) last author

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