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Title: Can we reduce hypoglycaemia with insulin detemir?
Authors: Mathieu, Chantal # ×
Issue Date: Sep-2004
Series Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity vol:28 issue:Suppl 2 pages:S35-S40
Abstract: Tight glycaemic control is essential for reducing the risk of long-term diabetic complications in people with type I or II diabetes. Intensive blood-glucose control attempts to normalise both pre- and postprandial glycaemia, while avoiding severe hypoglycaemia. A basal insulin, providing a low level of insulin to cover postprandial and overnight fasting periods, is central to intensive blood-glucose control. However, hypoglycaemia, particularly nocturnal hypoglycaemia, is a major treatment-related complication of therapy with most basal insulins currently available for use in clinical practice. This is a result of pronounced peaks in absorption, which lead to inappropriate hyperinsulinaemia following evening administration, and especially poorly reproducible pharmacokinetic profiles when injected subcutaneously. Indeed, for many patients and health-care providers, concern around hypoglycaemia forms a critical barrier to the attainment of tight glycaemic control. Insulin detemir is a novel long-acting analogue of human insulin designed to overcome these practical limitations. Clinical evidence from comparative studies with NPH insulin shows that insulin detemir provides a consistent and clinically relevant reduction in hypoglycaemic risk, especially for nocturnal events, at equivalent or better levels of glycaemic control.
URI: 
ISSN: 0307-0565
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Residents Medicine
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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