Title: Hippocampal involvement in the acquisition of relational associations, but not in the expression of a transitive inference task in mice
Authors: Van der Jeugd, Anneke
Goddyn, Hannelore
Laeremans, Annelies
Arckens, Lut
D'Hooge, Rudi
Verguts, Tom # ×
Issue Date: Feb-2009
Publisher: Amer psychological assoc
Series Title: Behavioral Neuroscience vol:123 issue:1 pages:109-114
Abstract: The hippocampus (HC) has been suggested to play a role in transitive inference (TI) on an ordered
sequence of stimuli. However, it has remained unclear whether HC is involved in the expression of TI,
or rather contributes to TI through its role in the acquisition of the sequence of elements (Frank, Rudy,
& O’Reilly, 2003). Presently, the authors compared the effects of excitotoxic dorsal HC lesions in C57BL
mice that received surgery before or after they were trained to discriminate between pairs of visual
stimuli. Performance on a subsequent TI task was worse in mice with pretraining lesions than in those
with posttraining lesions, which showed similar performance to shams without lesions. This indicates that
HC is not involved in the expression of TI, but may merely help to acquire the underlying representations
required for TI.
ISSN: 0735-7044
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Biological Psychology
Animal Physiology and Neurobiology Section - miscellaneous
× corresponding author
# (joint) last author

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