Title: Copper(II)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling
Authors: Singh, Brajendra Kumar ×
Appukkuttan, Prasad
Claerhout, Stijn
Parmar, Virinder Singh
Van der Eycken, Erik #
Issue Date: Apr-2006
Publisher: Amer chemical soc
Series Title: Organic letters vol:8 issue:9 pages:1863-1866
Abstract: [reaction: see text] Optimized conditions for the decoration of the 2(1H)-pyrazinone scaffold were developed by applying the Chan-Lam protocol. It was demonstrated that this Cu(II)-mediated cross-coupling reaction resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling at 0 degrees C, applying a mixture of bases Et(3)N/pyridine.
ISSN: 1523-7060
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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