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Title: Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno- or undifferentiated carcinoma of unknown primary: a randomised prospective phase II trial
Authors: Huebner, G ×
Link, H
Kohne, C. H
Stahl, M
Kretzschmar, A
Steinbach, S
Folprecht, G
Bernhard, H
Al-Batran, S. E
Schöffski, Patrick
Burkart, C
Kullmann, F
Otremba, B
Menges, M
Hoffmann, M
Kaiser, U
Aldaoud, A
Jahn, A #
Issue Date: Jan-2009
Publisher: Nature publishing group
Series Title: British Journal of Cancer vol:100 issue:1 pages:44-49
Abstract: Platinum/taxane combinations are widely used in patients with carcinoma of unknown primary (CUP), yielding response rates of 30% and median overall survival of 9-11 months in selected patients. Yet these combinations have not been subject to a randomised trial to overcome selection bias, a major problem in CUP. We randomised 92 patients to either paclitaxel/carboplatin (arm A) or the non-platinum non-taxane regimen gemcitabine/vinorelbine (arm B). The primary endpoint was rate of practicability as defined: application of >= 2 cycles of therapy ( 1) with a maximal delay of 1 week ( 2) and survival of >= 8 months ( 3). Practicability was shown in 52.4% (95% CI 36-68%) in arm A and in 42.2% ( 95% CI 28-58%) in arm B, respectively. The median overall survival, 1-year survival-rate and response rate of patients treated in arm A was 11.0 months, 38, and 23.8%, arm B 7.0 months, 29, and 20%. In conclusion, the paclitaxel/carboplatin regimen showed clinically meaningful activity in this randomised trial (Clinical trial registration number 219, 'Deutsches KrebsStudienRegister', German Cancer Society.)
ISSN: 0007-0920
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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