Title: Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
Authors: Dubois, Ludwig ×
Dresselaers, Tom
Landuyt, W
Paesmans, K
Mengesha, A
Wouters, B. G
Van Hecke, P
Theys, Jan
Lambin, P #
Issue Date: Mar-2007
Publisher: Nature publishing group
Series Title: British Journal of Cancer vol:96 issue:5 pages:758-761
Abstract: The potential utility of tumour-selective 5-fluorouracil treatment using attenuated Salmonella serovar typhimurium recombinant for cytosine deaminase (TAPET-CD) has been documented in experimental settings. The present data demonstrate that in vivo F-19-magnetic resonance spectroscopy measurements allow the outcome prediction of this prokaryotic-based therapy, demonstrating the necessity of non-invasive real-time imaging techniques for treatment monitoring.
ISSN: 0007-0920
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biomedical MRI
Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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